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Production of bioactive substances using fungal production systems


Fungal production systems are characterised by their robustness, a high level of secretion and their genetic accessibility. This makes fungal production systems ideal candidates for the target-oriented production of proteins, platform chemicals and bio-polymers.
After production, processing and purification of bio-active substances using appropriate fungal fermentation protocols and downstream processes, the products are analyzed for their potential applications in pharmaceutical or food industry. Targeted products can be both proteins and secondary metabolites. Furthermore, synthetic biology tools for Aspergillus niger are developed and established, aiming at the controlled synthesis of bio-active substances in fungal host strains.
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